Early-stage Favourable Anal Cancer: A Retrospective Analysis of Clinical Outcomes of a Moderately Low Dose Elective Nodal Intensity-modulated Radiotherapy Schedule

L Lestrade; T Zilli; M Kountouri; R Jumeau; O Matzinger; J Bourhis; R Miralbell; M Ozsahin; B De Bari

doi:10.1016/j.clon.2017.01.044

Early-stage Favourable Anal Cancer: A Retrospective Analysis of Clinical Outcomes of a Moderately Low Dose Elective Nodal Intensity-modulated Radiotherapy Schedule

Clin Oncol (R Coll Radiol). 2017 Jul;29(7):e105-e109. doi: 10.1016/j.clon.2017.01.044. Epub 2017 Feb 20.

Authors

L Lestrade¹, T Zilli², M Kountouri¹, R Jumeau³, O Matzinger⁴, J Bourhis³, R Miralbell¹, M Ozsahin³, B De Bari³

Affiliations

¹ Radiation Oncology, Geneva University Hospital - HUG, Geneva, Switzerland.
² Radiation Oncology, Geneva University Hospital - HUG, Geneva, Switzerland. Electronic address: [email protected].
³ Radiation Oncology, Centre Hospitalier Universitaire Vaudois - CHUV, Lausanne, Switzerland.
⁴ Radiation Oncology, Riviera Hospital, Vevey, Switzerland.

PMID: 28222958
DOI: 10.1016/j.clon.2017.01.044

Abstract

In this retrospective study we evaluated the long-term results of 35 early-stage favourable T1-2 N0 M0 anal cancer patients treated with intensity-modulated radiotherapy techniques combining low dose prophylactic inguinal-pelvic irradiation with dose-escalated boost. Optimal locoregional control and good tolerance makes this treatment a valuable alternative to brachytherapy boost and involved-field radiotherapy plans.

Keywords: Anal cancer; IMRT; early-stage; local control; radiotherapy; toxicity.

MeSH terms

Adult
Aged
Anus Neoplasms / pathology
Anus Neoplasms / radiotherapy*
Female
Humans
Male
Neoplasm Staging
Radiotherapy Dosage
Radiotherapy, Intensity-Modulated / methods*
Retrospective Studies
Treatment Outcome