Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria

Nat Microbiol. 2017 Feb 22:2:17001. doi: 10.1038/nmicrobiol.2017.1.

Authors

Muriel Masi¹, Matthieu Réfregiers², Klaas M Pos³, Jean-Marie Pagès¹

Affiliations

¹ Transporteurs Membranaires, Chimiorésistance et Drug Design, Aix-Marseille Université, IRBA, UMR-MD1, Facultés de Médecine et de Pharmacie, 13385 Marseille cedex05, France.
² DISCO beamline, Synchrotron Soleil, L'Orme des Merisiers Saint-Aubin - BP 48 91192, Gif-sur-Yvette cedex, France.
³ Membrane Transport Machineries, Institute of Biochemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt am Main, Germany.

PMID: 28224989
DOI: 10.1038/nmicrobiol.2017.1

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / metabolism*
Anti-Bacterial Agents / pharmacokinetics
Biological Transport, Active
Cell Membrane / metabolism*
Cell Wall / metabolism*
Diffusion
Gram-Negative Bacteria / drug effects
Gram-Negative Bacteria / metabolism*
Membrane Transport Proteins / metabolism
Permeability

Substances

Anti-Bacterial Agents
Membrane Transport Proteins