Commanding CNS Invasion: GM-CSF

Junjie Zhao; Lillian Sun; Xiaoxia Li

doi:10.1016/j.immuni.2017.02.003

Commanding CNS Invasion: GM-CSF

Immunity. 2017 Feb 21;46(2):165-167. doi: 10.1016/j.immuni.2017.02.003.

Authors

Junjie Zhao¹, Lillian Sun², Xiaoxia Li³

Affiliations

¹ Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.
² Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
³ Department of Immunology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA. Electronic address: [email protected].

Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF or Csf-2) is a pro-inflammatory mediator implicated in the pathogenesis of various autoimmune diseases. In this issue of Immunity, Spath et al. (2017) show that the dysregulated production of GM-CSF rather than IL-17 induces spontaneous immunopathology in a mouse model of CNS inflammation.

Publication types

Comment

MeSH terms

Animals
Granulocyte-Macrophage Colony-Stimulating Factor*
Inflammation
Interleukin-17*

Substances

Interleukin-17
Granulocyte-Macrophage Colony-Stimulating Factor

Grants and funding

P01 HL029582/HL/NHLBI NIH HHS/United States