1 *Department of Gastroenterology, Hepatology, and Nutrition †Shanghai Institute of Medical Genetics, Shanghai Children's Hospital ‡Department of Bioinformatics and Biostatistics, School of Life Science and Biotechnology, Shanghai Jiao Tong University §Key Laboratory of Molecular Embryology, Ministry of Health &Shanghai Key Laboratory of Embryo and Reproduction Engineering, Shanghai, China ||Department of Bioengineering, Bioinformatics Program, University of Illinois at Chicago, Chicago ¶Department of Anesthesiology, Shanghai Ninth People's Hospital (affiliated Shanghai Jiao Tong University School of Medicine) #Department of Children's Healthcare, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, China.