Real-time light dosimetry for intra-cavity photodynamic therapy: Application for pleural mesothelioma treatment

Photodiagnosis Photodyn Ther. 2017 Jun:18:155-161. doi: 10.1016/j.pdpdt.2017.02.011. Epub 2017 Feb 22.

Abstract

Complete and homogeneous illumination of the target is necessary for the success of a photodynamic therapy (PDT) procedure. In most applications, light dosimetry is done using detectors placed at strategic locations of the target. In this study we propose a novel approach based on the combination of light distribution modeling with spatial localization of the light applicator for real time estimation and display of the applied dose on medical images. The feasibility approach is demonstrated for intrapleural PDT of malignant pleural mesothelioma.

Keywords: Dosimetry; Imaging; Intra-cavity application; Light distribution modeling; Photodynamic therapy; Real time tracking.

MeSH terms

  • Computer Systems
  • Dose-Response Relationship, Drug
  • Dose-Response Relationship, Radiation
  • Feasibility Studies
  • Humans
  • Light
  • Mesothelioma / drug therapy*
  • Mesothelioma / pathology
  • Phantoms, Imaging
  • Photochemotherapy / methods*
  • Photometry / methods*
  • Photosensitizing Agents / administration & dosage*
  • Pleural Neoplasms / drug therapy*
  • Pleural Neoplasms / pathology
  • Radiometry / methods*
  • Radiotherapy Dosage
  • Treatment Outcome

Substances

  • Photosensitizing Agents