Syk expression and IgE-mediated histamine release in basophils as biomarkers for predicting the clinical efficacy of omalizumab

J Allergy Clin Immunol. 2017 May;139(5):1680-1682.e10. doi: 10.1016/j.jaci.2016.12.965. Epub 2017 Mar 1.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adult
  • Anti-Asthmatic Agents / therapeutic use*
  • Asthma / diagnosis
  • Asthma / drug therapy*
  • Basophils / drug effects*
  • Basophils / physiology
  • Biomarkers, Pharmacological / metabolism*
  • Disease Progression
  • Female
  • Gene Expression Regulation
  • Histamine Release / drug effects
  • Humans
  • Immunoglobulin E / metabolism
  • Male
  • Omalizumab / therapeutic use*
  • Prognosis
  • Quality of Life
  • Self Report
  • Syk Kinase / genetics
  • Syk Kinase / metabolism*
  • Treatment Outcome

Substances

  • Anti-Asthmatic Agents
  • Biomarkers, Pharmacological
  • Omalizumab
  • Immunoglobulin E
  • Syk Kinase