Downstaging of bilobar hepatocellular carcinoma after radioembolization with 90Y microspheres as a bridge to liver transplantation

Rev Esp Med Nucl Imagen Mol. 2017 Sep-Oct;36(5):329-332. doi: 10.1016/j.remn.2016.12.006. Epub 2017 Mar 6.
[Article in English, Spanish]

Abstract

Hepatic radioembolization with 90Y is an increasingly widely used locoregional therapy in the treatment of hepatocellular carcinoma. Its potential benefit has recently been described as a downstaging treatment, achieving a decreased tumour burden and allowing patients to be rescued for more radical treatments, such as liver transplantation. The case is presented of a patient diagnosed with multifocal bilobar hepatocellular carcinoma, Barcelona Clinic Liver Cancer (BCLC) intermediate stage, in whom treatment with 90Y achieved a satisfactory radiological response with a very significant reduction of tumour burden, allowing rescue with liver transplantation.

Keywords: (90)Y microspheres; Carcinoma hepatocelular; Downstaging; Hepatocellular carcinoma; Intra-arterial therapy; Liver transplantation; Microesferas de (90)Y; Radioembolización con (90)Y; Radioembolization; Terapia intraarterial; Trasplante hepático.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Hepatocellular / pathology*
  • Carcinoma, Hepatocellular / surgery
  • Carcinoma, Hepatocellular / therapy*
  • Embolization, Therapeutic / methods*
  • Humans
  • Liver Neoplasms / pathology*
  • Liver Neoplasms / surgery
  • Liver Neoplasms / therapy*
  • Liver Transplantation
  • Male
  • Microspheres
  • Middle Aged
  • Neoplasm Staging
  • Yttrium Radioisotopes / therapeutic use*

Substances

  • Yttrium Radioisotopes
  • Yttrium-90