Microbes and Diet-Induced Obesity: Fast, Cheap, and Out of Control

Cell Host Microbe. 2017 Mar 8;21(3):278-281. doi: 10.1016/j.chom.2017.02.021.

Abstract

Here I revisit our early experiments published in Cell Host & Microbe (Turnbaugh et al., 2008) showing that a diet rich in fat and simple sugars alters the gut microbiome in a manner that contributes to host adiposity, and reflect upon the remarkable advances and remaining challenges in this field.

Keywords: cellular memory; diet-induced obesity; gut microbiome; high-fat and high-sugar diets; metabolic disease; metagenomics; metatranscriptomics; microbial dynamics; multi-omics; nutrition.

MeSH terms

  • Animals
  • Cytosol / chemistry
  • Diet / adverse effects*
  • Diet / methods*
  • Gastrointestinal Microbiome / drug effects*
  • Humans
  • Obesity*