Collagen-Based Photoactive Agent for Tissue Bonding

ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9265-9270. doi: 10.1021/acsami.7b01984. Epub 2017 Mar 10.

Abstract

Using a combination of methacrylated collagen and the photosensitizer rose Bengal, a new light-activated biomimetic material for tissue sutureless bonding was developed. This formulation was cross-linked using green light. In vivo tests in mice demonstrate the suitability of the material for sutureless wound closure.

Keywords: collagen; cross-linking; rose Bengal; tissue photobonding; wound healing.

MeSH terms

  • Animals
  • Collagen / chemistry*
  • Cross-Linking Reagents
  • Mice
  • Photosensitizing Agents
  • Rose Bengal

Substances

  • Cross-Linking Reagents
  • Photosensitizing Agents
  • Rose Bengal
  • Collagen