Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E

Masuko Kobori; Yumiko Takahashi; Mutsumi Sakurai; Yinhua Ni; Guanliang Chen; Mayumi Nagashimada; Shuichi Kaneko; Tsuguhito Ota

doi:10.3390/ijms18030593

Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E

Int J Mol Sci. 2017 Mar 8;18(3):593. doi: 10.3390/ijms18030593.

Authors

Masuko Kobori¹, Yumiko Takahashi², Mutsumi Sakurai³, Yinhua Ni⁴, Guanliang Chen⁵, Mayumi Nagashimada⁶, Shuichi Kaneko⁷, Tsuguhito Ota⁸

Affiliations

¹ Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan. [email protected].
² Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan. [email protected].
³ Food Research Institute, National Agriculture and Food Resrach Organization, Tsukuba, Ibaraki 305-8642, Japan. [email protected].
⁴ Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. [email protected].
⁵ Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. [email protected].
⁶ Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. [email protected].
⁷ Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. [email protected].
⁸ Department of Cell Metabolism and Nutrition, Brain/Liver Interface Medicine Research Center, Kanazawa University, Kanazawa, Ishikawa 920-8640, Japan. [email protected].

Abstract

Astaxanthin alleviates hepatic lipid accumulation and peroxidation, inflammation, and fibrosis in mice with high-cholesterol, high-cholate, and high-fat (CL) diet-induced nonalcoholic steatohepatitis (NASH) [...].

Keywords: astaxanthin; comprehensive gene expression analysis; eukaryotic initiation factor-2 (EIF2); nonalcoholic steatohepatitis (NASH); peroxisome proliferator-activated receptor α (PPARA); vitamin E.

MeSH terms

Animals
Diet, High-Fat / adverse effects
Disease Models, Animal
Eukaryotic Initiation Factor-2 / metabolism
Gene Expression Profiling
Liver / drug effects*
Liver / metabolism*
Male
Mice
Mitochondria / drug effects
Mitochondria / genetics
Mitochondria / metabolism
Non-alcoholic Fatty Liver Disease / drug therapy
Non-alcoholic Fatty Liver Disease / etiology*
Non-alcoholic Fatty Liver Disease / metabolism*
Non-alcoholic Fatty Liver Disease / pathology
PPAR alpha / metabolism
PPAR delta / metabolism
Protein Interaction Mapping
Protein Interaction Maps
Retinoic Acid Receptor alpha / metabolism
Signal Transduction / drug effects
Transcriptome*
Vitamin E / pharmacology*
Xanthophylls / pharmacology

Substances

Eukaryotic Initiation Factor-2
PPAR alpha
PPAR delta
Retinoic Acid Receptor alpha
Xanthophylls
Vitamin E
astaxanthine