Abstract
A fraction which potently and specifically competed with 3H-PCP binding to rat membranes was isolated from human CSF. This substance ran just before the salts in Sephadex G-25 column and was eluted with low concentrations of acetonitrile in reverse phase HPLC, predicating that it may be a small hydrophilic compound with a MW. of less than 1,000 daltons.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Brain / metabolism
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Cell Membrane / metabolism
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Cerebrospinal Fluid / metabolism*
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Humans
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Rats
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Receptors, Neurotransmitter / metabolism*
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Receptors, Opioid / metabolism*
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Receptors, Phencyclidine
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Tissue Extracts / metabolism
Substances
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Receptors, Neurotransmitter
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Receptors, Opioid
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Receptors, Phencyclidine
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Tissue Extracts