Recurrent mutations in epigenetic modifiers and the PI3K/AKT/mTOR pathway in subcutaneous panniculitis-like T-cell lymphoma

Zhaoming Li; Lisha Lu; Zhiyuan Zhou; Weili Xue; Yingjun Wang; Mengyuan Jin; Yajuan Qiu; Wei Sun; Xuefei Fu; Xudong Zhang; Yu Chang; Feifei Nan; Jiaqin Yan; Guannan Wang; Zhenchang Sun; Xiaorui Fu; Ling Li; Xin Li; Xinhua Wang; Jingjing Wu; Lei Zhang; Mingzhi Zhang

doi:10.1111/bjh.14611

Recurrent mutations in epigenetic modifiers and the PI3K/AKT/mTOR pathway in subcutaneous panniculitis-like T-cell lymphoma

Br J Haematol. 2018 May;181(3):406-410. doi: 10.1111/bjh.14611. Epub 2017 Mar 14.

Authors

Zhaoming Li^{1

2}, Lisha Lu^{1

3}, Zhiyuan Zhou^{1

3}, Weili Xue^{1

3}, Yingjun Wang^{1

3}, Mengyuan Jin^{1

3}, Yajuan Qiu^{1

2}, Wei Sun⁴, Xuefei Fu⁴, Xudong Zhang^{1

2}, Yu Chang^{1

2}, Feifei Nan^{1

2}, Jiaqin Yan^{1

2}, Guannan Wang⁵, Zhenchang Sun^{1

2}, Xiaorui Fu^{1

2}, Ling Li^{1

2}, Xin Li^{1

2}, Xinhua Wang^{1

2}, Jingjing Wu^{1

2}, Lei Zhang^{1

2}, Mingzhi Zhang^{1

2}

Affiliations

¹ Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
² Lymphoma Diagnosis and Treatment Centre of Henan Province, Zhengzhou, China.
³ Institute of Clinical Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
⁴ Novogene Bioinformatics Technology Co, Ltd, Beijing, China.
⁵ Department of Pathology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

PMID: 28294301
DOI: 10.1111/bjh.14611

No abstract available

Keywords: PI3K/AKT/mTOR pathway; epigenetic modifiers; mutation; subcutaneouspanniculitis-like T-cell lymphoma; whole-exome sequencing.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Epigenesis, Genetic*
Female
Humans
Lymphoma, T-Cell, Cutaneous* / genetics
Lymphoma, T-Cell, Cutaneous* / metabolism
Lymphoma, T-Cell, Cutaneous* / pathology
Male
Mutation*
Panniculitis* / genetics
Panniculitis* / metabolism
Panniculitis* / pathology
Phosphatidylinositol 3-Kinases* / genetics
Phosphatidylinositol 3-Kinases* / metabolism
Proto-Oncogene Proteins c-akt* / genetics
Proto-Oncogene Proteins c-akt* / metabolism
Signal Transduction*
Skin Neoplasms / genetics
Skin Neoplasms / metabolism
Skin Neoplasms / pathology
TOR Serine-Threonine Kinases* / genetics
TOR Serine-Threonine Kinases* / metabolism

Substances

MTOR protein, human
Proto-Oncogene Proteins c-akt
TOR Serine-Threonine Kinases