Partial loss of genes might open therapeutic window

Bo Liu; Omar Abdel-Wahab

doi:10.7554/eLife.25996

Partial loss of genes might open therapeutic window

Elife. 2017 Mar 17:6:e25996. doi: 10.7554/eLife.25996.

Authors

Bo Liu¹, Omar Abdel-Wahab²

Affiliations

¹ Human Oncology and Pathogenesis Program, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States.
² Human Oncology and Pathogenesis Program and the Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, United States.

Abstract

The loss of genes that encode RNA splicing factors weakens cancer cells in a way that could be exploited by new approaches to treatment.

Keywords: CYCLOPS genes; SF3B1; cancer biology; cancer therapeutics; copy number alterations; human; human biology; medicine; mouse; spliceosome; target identification and validation.

Publication types

Comment

MeSH terms

Humans
Neoplasms*
Phosphoproteins*
RNA Splicing Factors

Substances

Phosphoproteins
RNA Splicing Factors
SF3B1 protein, human