Abstract
We have found that genomes of human T cell leukemia-lymphoma virus type I (HTLV-I), BK virus (BKV), and a hepatitis B virus (HBV) DNA sequence integrated into DNA of a hepatoma-derived cell line contain binding sites for nuclear factor 1 (NF-1), a cellular protein which binds to adenoviral and putative cellular origins of DNA replication. We suggest that cellular origins of DNA replication acquired by oncoviruses may play a role in malignant transformation after reintegration into the cellular genome by providing new targets for cellular factors initiating DNA replication and by perturbing the temporal order of replication.
MeSH terms
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Binding Sites
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CCAAT-Enhancer-Binding Proteins*
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism*
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DNA Replication*
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DNA, Viral / genetics*
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism*
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Deltaretrovirus / genetics
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Hepatitis B virus / genetics
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Humans
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NFI Transcription Factors
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Nuclear Proteins
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Oncogenic Viruses / genetics*
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Papillomaviridae / genetics
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Polyomaviridae
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Sequence Homology, Nucleic Acid
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Transcription Factors*
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Y-Box-Binding Protein 1
Substances
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CCAAT-Enhancer-Binding Proteins
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DNA, Viral
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DNA-Binding Proteins
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NFI Transcription Factors
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Nuclear Proteins
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Transcription Factors
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Y-Box-Binding Protein 1
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YBX1 protein, human