Eosinophilic Pustular Folliculitis in Children after Stem Cell Transplantation: An Eruption Distinct from Graft-Versus-Host Disease

Martin Theiler; Vikash S Oza; Erin F Mathes; Christopher C Dvorak; Timothy H McCalmont; Iwei Yeh; Robert Sidbury; Kelly M Cordoro

doi:10.1111/pde.13108

Eosinophilic Pustular Folliculitis in Children after Stem Cell Transplantation: An Eruption Distinct from Graft-Versus-Host Disease

Pediatr Dermatol. 2017 May;34(3):326-330. doi: 10.1111/pde.13108. Epub 2017 Mar 20.

Authors

Martin Theiler^{1

2}, Vikash S Oza³, Erin F Mathes^{4

5}, Christopher C Dvorak⁴, Timothy H McCalmont^{5

6}, Iwei Yeh^{5

6}, Robert Sidbury⁷, Kelly M Cordoro^{4

5}

Affiliations

¹ Department of Pediatric Dermatology, University Children's Hospital Zurich, Zurich, Switzerland.
² Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.
³ Ronald O. Perelman Department of Dermatology, School of Medicine, New York University, New York, New York.
⁴ Department of Pediatrics, University of California, San Francisco, California.
⁵ Department of Dermatology, University of California, San Francisco, California.
⁶ Department of Pathology, University of California, San Francisco, California.
⁷ Department of Pediatrics, Division of Dermatology, Seattle Children's Hospital and School of Medicine, University of Washington, Seattle, Washington.

PMID: 28317161
DOI: 10.1111/pde.13108

Abstract

Eosinophilic pustular folliculitis (EPF) is a rare cutaneous disorder that typically occurs in three clinical contexts: men, individuals who are immunosuppressed or have human immunodeficiency virus, and infants. A fourth subtype occurring 2 to 3 months after hematopoietic stem cell transplantation (HSCT) has recently been described in several adults. We report two cases of EPF arising in children after HSCT. It is important to recognize this form of EPF after HSCT and differentiate it from graft-versus-host disease since it responds readily to topical steroids and appears to have an excellent prognosis.

Publication types

Case Reports

MeSH terms

Child
Diagnosis, Differential
Eosinophilia / diagnosis*
Eosinophilia / drug therapy
Eosinophilia / etiology
Folliculitis / diagnosis*
Folliculitis / drug therapy
Folliculitis / etiology
Glucocorticoids / therapeutic use*
Graft vs Host Disease / diagnosis*
Humans
Immunosuppressive Agents / adverse effects*
Infant
Infant, Newborn
Male
Skin / pathology
Skin Diseases, Vesiculobullous / diagnosis*
Skin Diseases, Vesiculobullous / drug therapy
Skin Diseases, Vesiculobullous / etiology
Stem Cell Transplantation / adverse effects*

Substances

Glucocorticoids
Immunosuppressive Agents

Supplementary concepts

Eosinophilic pustular folliculitis