Leptin is associated with cardiopulmonary fitness independent of body-mass index and insulin sensitivity in adolescents with type 1 diabetes: a brief report from the EMERALD study

J Diabetes Complications. 2017 May;31(5):850-853. doi: 10.1016/j.jdiacomp.2017.02.019. Epub 2017 Mar 14.

Abstract

Cardiopulmonary fitness is decreased in type 1 diabetes for reasons that are incompletely understood. In this study, leptin was associated with exercise capacity independent of insulin sensitivity (IS) and body mass index (BMI), suggesting that leptin may relate to cardiopulmonary fitness by mechanisms beyond IS and/or obesity.

Keywords: Adiposity; Cardiopulmonary fitness; Insulin sensitivity; Leptin; Type 1 diabetes.

MeSH terms

  • Adiposity*
  • Adolescent
  • Adult
  • Biomarkers / blood
  • Body Mass Index
  • Cardiorespiratory Fitness
  • Child
  • Colorado
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / complications*
  • Diabetes Mellitus, Type 1 / metabolism
  • Diabetes Mellitus, Type 1 / physiopathology
  • Exercise Tolerance*
  • Female
  • Humans
  • Insulin Resistance*
  • Leptin / blood*
  • Male
  • Overweight / complications*
  • Oxygen Consumption
  • Pediatric Obesity / complications*
  • Sex Characteristics
  • Young Adult

Substances

  • Biomarkers
  • Leptin