Experimental Evolution to Study Virus Emergence

Nathan D Grubaugh; Kristian G Andersen

doi:10.1016/j.cell.2017.03.018

Experimental Evolution to Study Virus Emergence

Cell. 2017 Mar 23;169(1):1-3. doi: 10.1016/j.cell.2017.03.018.

Authors

Nathan D Grubaugh¹, Kristian G Andersen²

Affiliations

¹ Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA. Electronic address: [email protected].
² Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA 92037, USA; Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Scripps Translational Science Institute, La Jolla, CA 92037, USA. Electronic address: [email protected].

PMID: 28340335
DOI: 10.1016/j.cell.2017.03.018

Abstract

Understanding how viruses adapt to new environments and acquire new phenotypes is critical for developing comprehensive responses to outbreaks. By studying the emergence of vaccine-derived poliovirus outbreaks, Stern et al. describe how a combination of sequence analysis and experimental evolution can be used to reveal adaptive pathways.

MeSH terms

Biological Evolution
Disease Outbreaks
Poliomyelitis / epidemiology*
Poliovirus / genetics
Poliovirus Vaccine, Oral*

Substances

Poliovirus Vaccine, Oral

Abstract

MeSH terms

Substances

Grants and funding