The use of non-steroidal anti-inflammatory drugs in neurological diseases

Murat Terzi; Gamze Altun; Sedat Şen; Adem Kocaman; Arife Ahsen Kaplan; Kıymet Kübra Yurt; Süleyman Kaplan

doi:10.1016/j.jchemneu.2017.03.003

The use of non-steroidal anti-inflammatory drugs in neurological diseases

J Chem Neuroanat. 2018 Jan:87:12-24. doi: 10.1016/j.jchemneu.2017.03.003. Epub 2017 Mar 21.

Authors

Murat Terzi¹, Gamze Altun², Sedat Şen³, Adem Kocaman², Arife Ahsen Kaplan², Kıymet Kübra Yurt², Süleyman Kaplan²

Affiliations

¹ Department of Neurology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey. Electronic address: [email protected].
² Department of Histology and Embryology, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Turkey.
³ Department of Neurology, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey.

PMID: 28341179
DOI: 10.1016/j.jchemneu.2017.03.003

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) have been in use for many years and constitute a large part of prescriptions issued in daily practice. Although NSAIDs are used for many diseases in neurology, they have also been tested as a new therapeutic option for various other diseases. While their effects on headache and cerebrovascular diseases are well known, little is known about their impact on neurodegenerative diseases. This review discusses the use, effects and safety of NSAIDs in neurological diseases.

Keywords: Cyclooxygenase inhibition; Neurodegeneration; Neuroinflammation; Non-steroidal anti-inflammatory drugs; Prostaglandins.

Publication types

Review

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Humans
Neurodegenerative Diseases / drug therapy*

Substances

Anti-Inflammatory Agents, Non-Steroidal