Institutional profile: University of Florida Health Personalized Medicine Program

Larisa H Cavallari; Kristin W Weitzel; Amanda R Elsey; Xinyue Liu; Scott A Mosley; Donald M Smith; Benjamin J Staley; Almut G Winterstein; Carol A Mathews; Francesco Franchi; Fabiana Rollini; Dominick J Angiolillo; Petr Starostik; Michael J Clare-Salzler; David R Nelson; Julie A Johnson

doi:10.2217/pgs-2017-0028

Institutional profile: University of Florida Health Personalized Medicine Program

Pharmacogenomics. 2017 Apr;18(5):421-426. doi: 10.2217/pgs-2017-0028. Epub 2017 Mar 27.

Authors

Larisa H Cavallari^{1

2

3}, Kristin W Weitzel^{1

2

3}, Amanda R Elsey^{1

3}, Xinyue Liu⁴, Scott A Mosley^{1

2}, Donald M Smith^{1

2}, Benjamin J Staley^{4

5}, Almut G Winterstein^{4

6}, Carol A Mathews⁷, Francesco Franchi⁸, Fabiana Rollini⁸, Dominick J Angiolillo⁸, Petr Starostik⁹, Michael J Clare-Salzler^{3

9}, David R Nelson^{2

10}, Julie A Johnson^{1

2

3

10}

Affiliations

¹ Department of Pharmacotherapy & Translational Research, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
² Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.
³ Clinical & Translational Science Institute, University of Florida, Gainesville, FL 32610, USA.
⁴ Department of Pharmaceutical Outcomes & Policy, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
⁵ Department of Pharmacy, University of Florida Health Shands Hospital, Gainesville, FL 32608, USA.
⁶ Department of Epidemiology, Colleges of Medicine & Public Health & Health Professions, University of Florida, Gainesville, FL 32610, USA.
⁷ Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
⁸ Department of Medicine, College of Medicine, University of Florida, Jacksonville, FL 32209, USA.
⁹ Department of Pathology, Immunology & Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.
¹⁰ Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA.

Abstract

The University of Florida (UF) Health Personalized Medicine Program launched in 2012 with CYP2C19 genotyping for clopidogrel response at UF Health Shands Hospital. We have since expanded CYP2C19 genotyping to UF Health Jacksonville and established the infrastructure at UF Health to support clinical implementation for five additional gene-drug pairs: TPMT-thiopurines, IFNL3 (IL28B)-PEG IFN-α-based regimens, CYP2D6-opioids, CYP2D6/CYP2C19-antidepressants and CYP2C19-proton pump inhibitors. We are contributing to the evidence based on outcomes with genotype-guided therapy through pragmatic studies of our clinical implementations. In addition, we have developed a broad array of educational programs for providers, trainees and students that incorporate personal genotype evaluation to enhance participant learning.

Keywords: PEG-interferon; clopidogrel; education; genotype; implementation; opioids; pharmacogenetics; proton pump inhibitors; selective serotonin uptake inhibitors; thiopurines.

Publication types

Review

MeSH terms

Florida
Genetic Testing / methods*
Genetic Testing / trends
Health Education / methods*
Health Education / trends
Humans
Pharmacogenetics / education*
Pharmacogenetics / methods*
Pharmacogenetics / trends
Precision Medicine / methods*
Precision Medicine / trends
Universities* / trends

Abstract

Publication types

MeSH terms

Grants and funding