•Lichen sclerosus in females primarily involves the hairless anogenital skin.•Skin tissue outside this area is constitutionally not at risk for lichen sclerosus.•Transplantation into the vulvar field may turn skin susceptible to lichen sclerosus.•Tissue inherent positional information might affect lichen sclerosus susceptibility.
Keywords: Dermatoses; Lichen sclerosus; Positional information; Pudendal thigh skin flap; Vulvar cancer.