Abstract
The WORLD07 study characterizes lung cancer in Spanish women. This analysis investigated lung cancer features in never-smoking women. Of 2072 women recruited, 2035 were analyzed. Patient characteristics and demographics were similar for current/former smokers and never smokers. Among never smokers, 38.3% were exposed to passive smoking. Non-small-cell lung cancer was the most common type (78.8% of current/former smokers and 96.1% of never smokers) and adenocarcinoma the most common histology (69.1% and 83.4% respectively). There was a high incidence of lung cancer in Spanish never-smoking women and a high proportion (about 50%) had mutant epidermal growth factor receptor.
Keywords:
Lung cancer; Spanish women; never smokers; prognostic factors; smoking.
MeSH terms
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Adenocarcinoma / diagnosis
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Adenocarcinoma / epidemiology*
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Adenocarcinoma / genetics
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Adenocarcinoma / mortality
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Adenocarcinoma of Lung
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Aged
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Biomarkers, Tumor / genetics
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Carcinoma, Non-Small-Cell Lung / diagnosis
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Carcinoma, Non-Small-Cell Lung / epidemiology*
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Carcinoma, Non-Small-Cell Lung / genetics
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Carcinoma, Non-Small-Cell Lung / mortality
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Databases, Factual
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ErbB Receptors / genetics
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Female
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Genetic Predisposition to Disease
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Humans
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Incidence
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Kaplan-Meier Estimate
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Lung Neoplasms / diagnosis
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Lung Neoplasms / epidemiology*
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Lung Neoplasms / genetics
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Lung Neoplasms / mortality
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Middle Aged
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Mutation
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Phenotype
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Prospective Studies
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Risk Factors
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Sex Distribution
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Spain / epidemiology
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Tobacco Smoke Pollution / adverse effects*
Substances
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Biomarkers, Tumor
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Tobacco Smoke Pollution
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EGFR protein, human
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ErbB Receptors