Progressive multifocal leukoencephalopathy due to John Cunningham (JC) virus following allogeneic haematopoietic cell transplantation

Antivir Ther. 2017;22(8):721-725. doi: 10.3851/IMP3162.

Abstract

Progressive multifocal leukoencephalopathy (PML) is an uncommon infectious complication post allogeneic stem cell transplant. We present a case report of a patient developing this complication with a review of the current literature. It also describes the first use of artesunate in a clinical case of PML with no beneficial effect.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Biomarkers
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain / virology
  • Graft vs Host Disease / drug therapy
  • Graft vs Host Disease / etiology
  • Graft vs Host Disease / prevention & control
  • Hematopoietic Stem Cell Transplantation / adverse effects*
  • Humans
  • Immunoglobulins, Intravenous / therapeutic use
  • JC Virus* / genetics
  • Leukoencephalopathy, Progressive Multifocal / diagnosis*
  • Leukoencephalopathy, Progressive Multifocal / drug therapy
  • Leukoencephalopathy, Progressive Multifocal / etiology*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Transplantation, Homologous

Substances

  • Biomarkers
  • Immunoglobulins, Intravenous