Abstract
The complete sequence of the gene coding for the S antigen from the Wellcome (West African) strain of Plasmodium falciparum has been obtained. It contains a central repetitive region consisting of 65 copies of a partially degenerate 24 bp sequence, coding for a conserved 8 amino acid repeat (Gly Pro Asn Ser Asp Gly Asp Lys). The repeat sequence is different from those of S antigens characterised in other strains and thus represents a new S antigen serotype.
MeSH terms
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Amino Acid Sequence
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Animals
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Antigens, Protozoan / genetics*
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Base Sequence
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Cloning, Molecular
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Codon / genetics
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DNA / genetics
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DNA Restriction Enzymes
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Deoxyribonuclease EcoRI
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Deoxyribonuclease HindIII
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Genes*
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Molecular Sequence Data
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Nucleic Acid Hybridization
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Plasmodium falciparum / genetics*
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Plasmodium falciparum / immunology
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Repetitive Sequences, Nucleic Acid
Substances
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Antigens, Protozoan
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Codon
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DNA
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DNA Restriction Enzymes
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Deoxyribonuclease EcoRI
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Deoxyribonuclease HindIII