Mild, Redox-Neutral Alkylation of Imines Enabled by an Organic Photocatalyst

ACS Catal. 2017 Mar 3;7(3):1766-1770. doi: 10.1021/acscatal.6b03665. Epub 2017 Feb 6.

Abstract

An operationally simple, mild, redox-neutral method for the photoredox alkylation of imines is reported. Utilizing an inexpensive organic photoredox catalyst, alkyl radicals are readily generated from the single-electron oxidation of ammonium alkyl bis(catecholato)silicates and are subsequently engaged in a C-C bond-forming reaction with imines. The process is highly selective, metal-free, and does not require a large excess of the alkylating reagent or the use of acidic additives.

Keywords: hypervalent silicon; imines; photocatalysis; radical alkylation; visible light.