Mitochondrial replacement by pre-pronuclear transfer in human embryos

Keliang Wu; Tailai Chen; Sexin Huang; Cuiqing Zhong; Junhao Yan; Xiaoyu Zhang; Jinsong Li; Yuan Gao; Han Zhao; Zi-Jiang Chen

doi:10.1038/cr.2017.48

Mitochondrial replacement by pre-pronuclear transfer in human embryos

Cell Res. 2017 Jun;27(6):834-837. doi: 10.1038/cr.2017.48. Epub 2017 Apr 4.

Authors

Keliang Wu^{1

2

3

4

5}, Tailai Chen^{1

2

3}, Sexin Huang^{1

2

3}, Cuiqing Zhong^{4

5}, Junhao Yan^{1

2

3}, Xiaoyu Zhang^{6

7}, Jinsong Li^{6

7}, Yuan Gao^{1

2

3}, Han Zhao^{1

2

3}, Zi-Jiang Chen^{1

2

3

4

5}

Affiliations

¹ Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250001, China.
² National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, Shandong 250001, China.
³ The Key laboratory for Reproductive Endocrinology of Ministry of Education, Jinan, Shandong 250001, China.
⁴ Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China.
⁵ Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Shanghai 200135, China.
⁶ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China.
⁷ Shanghai Key Laboratory of Molecular Andrology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science, Shanghai 200031, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Blastocyst / metabolism
DNA, Mitochondrial / genetics
Embryo, Mammalian / metabolism*
Embryonic Stem Cells / metabolism
Humans
Mitochondrial Replacement Therapy*
Nuclear Transfer Techniques*
Oocytes / metabolism

Substances

DNA, Mitochondrial