T cells are required for coxsackievirus B1 induced murine polymyositis

S R Ytterberg; M L Mahowald; R P Messner

T cells are required for coxsackievirus B1 induced murine polymyositis

J Rheumatol. 1988 Mar;15(3):475-8.

Authors

S R Ytterberg¹, M L Mahowald, R P Messner

Affiliation

¹ Department of Medicine, Minneapolis Veterans Administration Medical Center, MN 55417.

PMID: 2837572

Abstract

Murine polymyositis (PM) induced by coxsackievirus B1 (CVB1) has been used as a model of human PM. Our study was undertaken to investigate the role of T cells in CVB1 induced PM by examining disease development in neonatally thymectomized mice. Clinical weakness and histological inflammatory myositis occurred in 42.7% of sham operated animals but only 7.7% of thymectomized mice. These experiments demonstrate the importance of T cells in the pathogenesis of this virus induced autoimmune disorder.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Coxsackievirus Infections*
Disease Susceptibility
Enterovirus B, Human
Lymphocytes / physiology*
Mice
Mice, Inbred Strains
Muscles / pathology
Muscles / physiopathology
Myositis / etiology*
Myositis / pathology
Myositis / physiopathology
Necrosis
Thymectomy