Brain iron accumulation in Wilson's disease: A longitudinal imaging case study during anticopper treatment using 7.0T MRI and transcranial sonography

J Magn Reson Imaging. 2018 Jan;47(1):282-285. doi: 10.1002/jmri.25702. Epub 2017 Apr 4.

Petr Dusek^{1

2}, David Skoloudik^{1

3}, Jana Maskova¹, Till Huelnhagen⁴, Radan Bruha⁵, Daniela Zahorakova⁶, Thoralf Niendorf^{4

7}, Evzen Ruzicka¹, Susanne A Schneider⁸, Jens Wuerfel^{9

10}

¹ Department of Neurology and Center of Clinical Neuroscience, Charles University, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic.
² Department of Radiology, Charles University, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic.
³ Department of Nursing, Faculty of Health Science, Palacky University Olomouc, Czech Republic.
⁴ Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
⁵ 4th Department of Internal Medicine, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic.
⁶ Department of Pediatrics and Adolescent Medicine, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic.
⁷ Experimental and Clinical Research Center, Charité-Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
⁸ Department of Neurology, Ludwig-Maximilians-University, Munich, Germany.
⁹ Medical Imaging Analysis Center AG and qbig, Department of Biomedical Engineering, University Basel, Basel, Switzerland.
¹⁰ NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Abstract

5 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:282-285.

Keywords: Wilson's disease; iron accumulation; relaxometry; transcranial sonography; ultra-high field MRI.