A case of breakthrough Candida parapsilosis fungemia during micafungin therapy for a Candida glabrata bloodstream infection

Yuta Norimatsu; Daiichi Morii; Asako Kogure; Taeko Hamanaka; Yoshihiro Kuwano; Takayuki Yokozawa; Toshimi Oda

doi:10.1016/j.mmcr.2017.03.002

A case of breakthrough Candida parapsilosis fungemia during micafungin therapy for a Candida glabrata bloodstream infection

Med Mycol Case Rep. 2017 Mar 23:16:1-3. doi: 10.1016/j.mmcr.2017.03.002. eCollection 2017 Jun.

Authors

Yuta Norimatsu¹, Daiichi Morii², Asako Kogure³, Taeko Hamanaka³, Yoshihiro Kuwano³, Takayuki Yokozawa⁴, Toshimi Oda¹

Affiliations

¹ Department of Infectious Diseases, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo 187-8510, Japan.
² Department of Infectious Diseases, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo 187-8510, Japan; Department of Infection Control and Prevention Graduate School of Medicine, Osaka University, 2-15 Yamadaoka, Suita, Osaka 565-0871, Japan.
³ Department of Dermatology, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo 187-8510, Japan.
⁴ Department of Clinical Laboratory, Showa General Hospital, 8-1-1 Hanakoganei, Kodaira, Tokyo 187-8510, Japan.

Abstract

We describe a case of breakthrough Candida parapsilosis fungemia in an 80-year-old woman with pyoderma gangrenosum and rheumatoid arthritis. C. parapsilosis was detected in blood culture while the patient was treated with micafungin for a Candida glabrata bloodstream infection. The breakthrough infection was successfully treated with liposomal amphotericin B.

Keywords: Breakthrough infection; Candida glabrata; Candida parapsilosis; Micafungin; Pyoderma gangrenosum.