Abstract
A survey of 461 HIV-infected Kenyan children receiving antiretroviral therapy found 143 (31%) failing virologically. Drug resistance mutations were found in 121; 37 had L74V/I mutations, with 95% receiving abacavir (ABC)-containing regimens. L74V/I was associated with current ABC usage (P = 0.0001). L74V/I may be more prevalent than previously realized in children failing ABC-containing regimens, even when time on treatment has been short. Ongoing rigorous pediatric drug resistance surveillance is needed.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / therapeutic use
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Child
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Child, Preschool
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Cross-Sectional Studies
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Dideoxynucleosides / pharmacology*
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Dideoxynucleosides / therapeutic use
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Drug Resistance, Viral / drug effects*
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Drug Resistance, Viral / genetics
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HIV Infections / drug therapy
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HIV Infections / genetics*
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HIV Infections / virology*
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HIV-1 / drug effects
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HIV-1 / genetics*
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Humans
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Kenya
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Treatment Failure
Substances
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Anti-HIV Agents
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Dideoxynucleosides
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abacavir