Nationwide epidemiological survey of idiopathic sudden sensorineural hearing loss in Japan

Ryosuke Kitoh; Shin-Ya Nishio; Kaoru Ogawa; Sho Kanzaki; Naohito Hato; Michihiko Sone; Satoshi Fukuda; Akira Hara; Tetsuo Ikezono; Kotaro Ishikawa; Satoshi Iwasaki; Kimitaka Kaga; Seiji Kakehata; Atsushi Matsubara; Tatsuo Matsunaga; Takaaki Murata; Yasushi Naito; Takashi Nakagawa; Kazunori Nishizaki; Yoshihiro Noguchi; Hajime Sano; Hiroaki Sato; Mikio Suzuki; Hideo Shojaku; Haruo Takahashi; Hidehiko Takeda; Testuya Tono; Hiroshi Yamashita; Tatsuya Yamasoba; Shin-Ichi Usami

doi:10.1080/00016489.2017.1297537

Nationwide epidemiological survey of idiopathic sudden sensorineural hearing loss in Japan

Acta Otolaryngol. 2017;137(sup565):S8-S16. doi: 10.1080/00016489.2017.1297537. Epub 2017 Apr 10.

Authors

Ryosuke Kitoh¹, Shin-Ya Nishio¹, Kaoru Ogawa², Sho Kanzaki², Naohito Hato³, Michihiko Sone⁴, Satoshi Fukuda⁵, Akira Hara⁶, Tetsuo Ikezono⁷, Kotaro Ishikawa⁸, Satoshi Iwasaki⁹, Kimitaka Kaga¹⁰, Seiji Kakehata¹¹, Atsushi Matsubara¹², Tatsuo Matsunaga¹⁰, Takaaki Murata¹³, Yasushi Naito¹⁴, Takashi Nakagawa¹⁵, Kazunori Nishizaki¹⁶, Yoshihiro Noguchi¹, Hajime Sano¹⁷, Hiroaki Sato¹⁸, Mikio Suzuki¹⁹, Hideo Shojaku²⁰, Haruo Takahashi²¹, Hidehiko Takeda²², Testuya Tono²³, Hiroshi Yamashita²⁴, Tatsuya Yamasoba²⁵, Shin-Ichi Usami¹

Affiliations

¹ a Department of Otorhinolaryngology , Shinshu University School of Medicine , Matsumoto , Japan.
² b Department of Otorhinolaryngology Head and Neck Surgery , Keio University School of Medicine , Tokyo , Japan.
³ c Department of Otolaryngology , Ehime University School of Medicine , Toon , Japan.
⁴ d Department of Otorhinolaryngology , Nagoya University, Graduate School of Medicine , Nagoya , Japan.
⁵ e Department of Otolaryngology-Head and Neck Surgery , Hokkaido University Graduate School of Medicine , Sapporo , Japan.
⁶ f Department of Otolaryngology, Faculty of Medicine , University of Tsukuba , Tsukuba , Japan.
⁷ g Department of Otorhinolaryngology , Saitama School of medicine , Moroyama , Japan.
⁸ h Department of Otolaryngology, Hospital , National Rehabilitation Center for Persons with Disabilities , Tokorozawa , Japan.
⁹ i Department of Otolaryngology , International University of Health and Welfare, Mita Hospital , Tokyo , Japan.
¹⁰ j Division of Hearing and Balance Research , National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center , Tokyo , Japan.
¹¹ k Department of Otorhinolaryngology , Yamagata University School of Medicine , Yamagata , Japan.
¹² l Department of Otorhinolaryngology , Hirosaki University Graduate School of Medicine , Hirosaki , Japan.
¹³ m Department of Otolaryngology , Gunma University Graduate School of Medicine , Maebashi , Japan.
¹⁴ n Department of Otolaryngology , Kobe City Medical Center General Hospital , Kobe , Japan.
¹⁵ o Department of Otorhinolaryngology , Kyushu University Graduate School of Medical Sciences , Fukuoka , Japan.
¹⁶ p Department of Otolaryngology-Head and Neck Surgery , Okayama University Graduate School of Medicine, Dentistry and Pharmacy , Okayama , Japan.
¹⁷ q Department of Otolaryngology , Kitasato University School of Medicine , Sagamihara , Japan.
¹⁸ r Department of Otorhinolaryngology , Iwate Medical University , Morioka , Japan.
¹⁹ s Department of Otorhinolaryngology, Head and Neck Surgery, Graduate School of Medicine , University of the Ryukyus , Nishihara , Japan.
²⁰ t Department of Otorhinolaryngology, Head and Neck Surgery , University of Toyama , Toyama , Japan.
²¹ u Department of Otolaryngology , Nagasaki University Faculty of Medicine , Nagasaki , Japan.
²² v Department of Otolaryngology , Okinaka Memorial Institute for Medical Research, Toranomon Hospital , Tokyo , Japan.
²³ w Department of Otolaryngology, Faculty of Medicine , University of Miyazaki , Miyazaki , Japan.
²⁴ x Department of Otolaryngology , Yamaguchi University Graduate School of Medicine , Ube , Japan.
²⁵ y Department of Otolaryngology, Faculty of Medicine , University of Tokyo , Tokyo , Japan.

PMID: 28394652
DOI: 10.1080/00016489.2017.1297537

Abstract

Objectives: Using a large-scale nationwide survey database, we investigated the epidemiological characteristics for idiopathic SSNHL in Japan.

Methods: The subjects for this analysis were patients registered in a Japanese multicentre database between April 2014 and March 2016. A total of 3419 idiopathic SSNHL patients were registered in the database, and the clinical characteristics of the idiopathic SSNHL patients were obtained. Several factors associated with the severity of hearing impairment and prognosis were then investigated. Statistical analysis was performed to clarify the factors associated with the severity of hearing impairment and prognosis.

Results: There were significant correlations between the severity of hearing loss and diabetes mellitus, kidney disease, past history of brain infarction, heart disease, age (under 16 years/elderly), and symptoms of vertigo/dizziness. We also analyzed the prognostic factors for idiopathic SSNHL, and found that the severity of hearing loss (Grade 3 or 4), heart disease, aged 65 years or over, time from onset to treatment (over 7 days), and symptoms of vertigo/dizziness were all significantly related to poor prognosis.

Conclusion: The present large-scale clinical survey revealed current epidemiological trends for idiopathic sudden sensorineural hearing loss (SSNHL) and various factors associated with the severity of hearing impairment and prognosis.

Keywords: Idiopathic sudden sensorineural hearing loss; corticosteroids; epidemiological survey; intratympanic; prognostic factors; severity of hearing impairment.

MeSH terms

Adrenal Cortex Hormones / therapeutic use
Aged
Female
Hearing Loss, Sensorineural / diagnosis
Hearing Loss, Sensorineural / drug therapy
Hearing Loss, Sensorineural / epidemiology*
Hearing Loss, Sudden / diagnosis
Hearing Loss, Sudden / drug therapy
Hearing Loss, Sudden / epidemiology*
Humans
Japan / epidemiology
Male
Middle Aged
Prognosis

Substances

Adrenal Cortex Hormones