An abscopal effect in a case of concomitant treatment of locally and peritoneally recurrent gastric cancer using adoptive T-cell immunotherapy and radiotherapy

Hiro Sato; Yoshiyuki Suzuki; Yuya Yoshimoto; Shin-Ei Noda; Kazutoshi Murata; Yosuke Takakusagi; Atsushi Okazaki; Tetsuo Sekihara; Takashi Nakano

doi:10.1002/ccr3.758

An abscopal effect in a case of concomitant treatment of locally and peritoneally recurrent gastric cancer using adoptive T-cell immunotherapy and radiotherapy

Clin Case Rep. 2017 Feb 15;5(4):380-384. doi: 10.1002/ccr3.758. eCollection 2017 Apr.

Authors

Hiro Sato¹, Yoshiyuki Suzuki², Yuya Yoshimoto¹, Shin-Ei Noda¹, Kazutoshi Murata¹, Yosuke Takakusagi³, Atsushi Okazaki⁴, Tetsuo Sekihara⁵, Takashi Nakano¹

Affiliations

¹ Department of Radiation Oncology Gunma University Graduate School of Medicine Maebashi Japan.
² Department of Radiation Oncology Fukushima Medical University Fukushima Japan.
³ Oncology Center Hidaka Hospital Takasaki Japan.
⁴ Department of Radiation Oncology Tsuboi Cancer Center Hospital Koriyama Japan.
⁵ Department of Urology Hidaka Hospital Takasaki Japan.

Abstract

The mechanism of abscopal effect is becoming clear by the progress of cancer immunology. A 54-year-old male with recurrent gastric cancer presented an abscopal effect after radiotherapy with concurrent adoptive T-cell immunotherapy (immunoradiotherapy). Immunoradiotherapy has potential to induce abscopal effect by strengthening systemic antitumor immunity even in recurrent cancer.

Keywords: Abscopal effect; adoptive T‐cell immunotherapy; gastric cancer; peritoneal dissemination; radiotherapy.

Publication types

Case Reports