The SEMIZENTRAL infrastructure approach has been developed for fast growing cities, to meet their challenges regarding water supply as well as biowaste and wastewater (WW) treatment. The world's first full-scale SEMIZENTRAL Resource Recovery reference plant has been implemented in Qingdao (PR China). Greywater (GW) and blackwater (BW) are collected and treated separately. Measurement of influent concentrations revealed significant differences, compared with the design values. Values from the literature for GW and BW characteristics vary more markedly than for municipal WW; recommended design values are still lacking. Moreover, cross-connections between GW and BW can influence the influent characteristics considerably. Consequences for the design of GW and BW treatment are evaluated for boundary conditions, which require high effluent quality for both treatment modules. Model calculations illustrate the significant influence of uncertain WW characteristics on the required aeration basin volume and oxygen demand for GW and BW treatment; however, uncertainties are considerably reduced for the combination of these modules. Thus, a flexible design of the treatment plant is required. A possible concept for such a design is presented.