Comparison between the allelic frequency distribution of the Ha-ras 1 locus in normal individuals and patients with lymphoma, breast, and ovarian cancer

B Corell; B Zoll

doi:10.1007/BF00366247

Comparison between the allelic frequency distribution of the Ha-ras 1 locus in normal individuals and patients with lymphoma, breast, and ovarian cancer

Hum Genet. 1988 Jul;79(3):255-9. doi: 10.1007/BF00366247.

Authors

B Corell¹, B Zoll

Affiliation

¹ Institut für Humangenetik der Universität, Göttingen, Federal Republic of Germany.

PMID: 2841224
DOI: 10.1007/BF00366247

Abstract

Analysis of 426 alleles of the human Ha-ras 1 locus in DNA samples of cancer patients and controls reveals no obvious association between specific restriction fragments and a genetic predisposition to malignancy. However, differences in the allele distribution in leukocyte and tumour DNAs of cancer patients may be related to an involvement of the Ha-ras 1 gene in tumorigenesis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles*
Breast Neoplasms / genetics*
DNA / genetics
DNA / isolation & purification
DNA Restriction Enzymes
DNA, Neoplasm / genetics
DNA, Neoplasm / isolation & purification
Female
Gene Frequency*
Genes, ras*
Humans
Leukocytes / cytology
Lymphoma / genetics*
Nucleic Acid Hybridization
Ovarian Neoplasms / genetics*
Reference Values

Substances

DNA, Neoplasm
DNA
DNA Restriction Enzymes