A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study

B Risslegger; T Zoran; M Lackner; M Aigner; F Sánchez-Reus; A Rezusta; A Chowdhary; S J Taj-Aldeen; M C Arendrup; S Oliveri; D P Kontoyiannis; A Alastruey-Izquierdo; K Lagrou; G Lo Cascio; J F Meis; W Buzina; C Farina; M Drogari-Apiranthitou; A Grancini; A M Tortorano; B Willinger; A Hamprecht; E Johnson; L Klingspor; V Arsic-Arsenijevic; O A Cornely; J Meletiadis; W Prammer; V Tullio; J-J Vehreschild; L Trovato; R E Lewis; E Segal; P-M Rath; P Hamal; M Rodriguez-Iglesias; E Roilides; S Arikan-Akdagli; A Chakrabarti; A L Colombo; M S Fernández; M T Martin-Gomez; H Badali; G Petrikkos; N Klimko; S M Heimann; J Houbraken; O Uzun; M Edlinger; S de la Fuente; C Lass-Flörl

doi:10.1016/j.cmi.2017.04.012

A prospective international Aspergillus terreus survey: an EFISG, ISHAM and ECMM joint study

Clin Microbiol Infect. 2017 Oct;23(10):776.e1-776.e5. doi: 10.1016/j.cmi.2017.04.012. Epub 2017 Apr 13.

Authors

B Risslegger¹, T Zoran¹, M Lackner¹, M Aigner¹, F Sánchez-Reus², A Rezusta³, A Chowdhary⁴, S J Taj-Aldeen⁵, M C Arendrup⁶, S Oliveri⁷, D P Kontoyiannis⁸, A Alastruey-Izquierdo⁹, K Lagrou¹⁰, G Lo Cascio¹¹, J F Meis¹², W Buzina¹³, C Farina¹⁴, M Drogari-Apiranthitou¹⁵, A Grancini¹⁶, A M Tortorano¹⁷, B Willinger¹⁸, A Hamprecht¹⁹, E Johnson²⁰, L Klingspor²¹, V Arsic-Arsenijevic²², O A Cornely²³, J Meletiadis²⁴, W Prammer²⁵, V Tullio²⁶, J-J Vehreschild²⁷, L Trovato²⁸, R E Lewis²⁹, E Segal³⁰, P-M Rath³¹, P Hamal³², M Rodriguez-Iglesias³³, E Roilides³⁴, S Arikan-Akdagli³⁵, A Chakrabarti³⁶, A L Colombo³⁷, M S Fernández³⁸, M T Martin-Gomez³⁹, H Badali⁴⁰, G Petrikkos⁴¹, N Klimko⁴², S M Heimann⁴³, J Houbraken⁴⁴, O Uzun⁴⁵, M Edlinger⁴⁶, S de la Fuente⁴⁷, C Lass-Flörl⁴⁸

Affiliations

¹ Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
² Servei de Microbiologia, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain.
³ Microbiologia, Hospital Universitario Miguel Servet, IIS Aragon, Universidad de Zaragoza, Zaragoza, Spain.
⁴ Department of Medical Mycology, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India.
⁵ Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.
⁶ Statens Serum Institute, Unit of Mycology, & Department of Clinical Microbiology, Copenhagen University, Rigshospitalet, Copenhagen, Denmark.
⁷ Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
⁸ The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
⁹ National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain.
¹⁰ Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium.
¹¹ Unità Operativa Complessa di Microbiologia e virologia, Dipartimento di Patologia e diagnostica, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
¹² Department of Medical Microbiology and Infectious Diseases, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.
¹³ Institute of Hygiene, Microbiology and Environmental Medicine, Medical University of Graz, Graz, Austria.
¹⁴ Microbiology Institute, ASST Papa Giovanni XXIII, Bergamo, Italy.
¹⁵ Infectious Diseases Research Laboratory, 4(th) Department of Internal Medicine, ATTIKON University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
¹⁶ Laboratorio Centrale di Analisi Chimico Cliniche e Microbiologia, IRCCS Foundation, Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
¹⁷ Department of Biomedical Sciences for Health, Università degli Studi di Milano, Milan, Italy.
¹⁸ Department of Laboratory Medicine, Division of Clinical Microbiology, Medical University of Vienna, Vienna, Austria.
¹⁹ Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany.
²⁰ Mycology Reference Laboratory, Public Health England, Bristol, UK.
²¹ Karolinska Institutet, Department of Laboratory Medicine, F 68, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
²² National Reference Medical Mycology Laboratory, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
²³ Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Department I of Internal Medicine, Clinical Trials Centre Cologne (ZKS Köln), Centre for Integrated Oncology (CIO Köln-Bonn), German Centre for Infection Research (DZIF), University of Cologne, Cologne, Germany.
²⁴ Clinical Microbiology Laboratory, National Kapodistrian University of Athens, ATTIKON University Hospital Athens, Athens, Greece.
²⁵ Department of Hygiene and Medical Microbiology, Klinikum Wels-Grieskirchen, Wels, Austria.
²⁶ Department of Public Health and Pediatrics, Microbiology Division, Turin, Italy.
²⁷ Department I for Internal Medicine, University Hospital of Cologne, Cologne and German Centre for Infection Research, Partner Site Bonn-Cologne, Germany.
²⁸ A.O.U. Policlinico Vittorio Emanuele Catania, Biometec - University of Catania, Italy.
²⁹ Infectious Diseases Unit, S. Orsola-Malpighi, Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
³⁰ Department of Clinical Microbiology and Immunology, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
³¹ Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
³² Department of of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Czech Republic.
³³ Clinical Microbiology, Puerta del Mar University Hospital, University of Cádiz, Cádiz, Spain.
³⁴ Infectious Diseases Unit, 3(rd) Department of Paediatrics, Faculty of Medicine, Aristotle University School of Health Sciences, Hippokration General Hospital, Thessaloniki, Greece.
³⁵ Department of Medical Microbiology, Hacettepe University Medical School, Ankara, Turkey.
³⁶ Division of Mycology, Department of Medial Microbiology, Chandigarh, India.
³⁷ Escola Paulista de Medicina, Federal University of São Paulo, São Paulo, Brazil.
³⁸ Departmento de Micología, Instituto de Medicina Regional, Universidad Nacional del Nordeste, CONICET, Resistencia, Argentina.
³⁹ Division of Clinical Mycology, Department of Microbiology, Vall d'Hebron University Hospital, Barcelona, Spain.
⁴⁰ Department of Medical Mycology and Parasitology/Invasive Fungi Research Centre, Mazandaran University of Medical Sciences, Sari, Iran.
⁴¹ School of Medicine, European University Cyprus, Nicosia, Cyprus.
⁴² Department of Clinical Mycology, Allergy and Immunology, North Western State Medical University, Saint Petersburg, Russia.
⁴³ Department I for Internal Medicine, University Hospital of Cologne, Cologne, Germany.
⁴⁴ CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.
⁴⁵ Hacettepe University Medical School, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.
⁴⁶ Department of Medical Statistics, Informatics and Health Economics, Medical University of Innsbruck, Innsbruck, Austria.
⁴⁷ Department of Dermatology, Hospital Ernest Lluch Martin, Calatayud, Zaragoza, Spain.
⁴⁸ Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria. Electronic address: [email protected].

PMID: 28412383
DOI: 10.1016/j.cmi.2017.04.012

Abstract

Objectives: A prospective international multicentre surveillance study was conducted to investigate the prevalence and amphotericin B susceptibility of Aspergillus terreus species complex infections.

Methods: A total of 370 cases from 21 countries were evaluated.

Results: The overall prevalence of A. terreus species complex among the investigated patients with mould-positive cultures was 5.2% (370/7116). Amphotericin B MICs ranged from 0.125 to 32 mg/L, (median 8 mg/L).

Conclusions: Aspergillus terreus species complex infections cause a wide spectrum of aspergillosis and the majority of cryptic species display high amphotericin B MICs.

Keywords: Amphotericin B; Aspergillosis; Aspergillus terreus; Crytic species; In vitrosusceptibility.

Publication types

Multicenter Study

MeSH terms

Amphotericin B / pharmacology
Antifungal Agents / pharmacology
Aspergillosis / epidemiology*
Aspergillosis / microbiology*
Aspergillus / classification*
Aspergillus / drug effects
Aspergillus / isolation & purification*
Epidemiological Monitoring
Europe / epidemiology
Humans
Microbial Sensitivity Tests
Prevalence
Prospective Studies

Substances

Antifungal Agents
Amphotericin B