During 2016, eight Neisseria gonorrhoeae isolates from 7 patients in Hawaii were resistant to azithromycin; 5 had decreased in vitro susceptibility to ceftriaxone. Genomic analysis demonstrated a distinct phylogenetic clade when compared with local contemporary strains. Continued evolution and widespread transmission of these strains might challenge the effectiveness of current therapeutic options.
Keywords: Hawaii; Neisseria gonorrhoeae; STD; STI; United States; antimicrobial resistance; azithromycin; bacteria; bacterial infection; ceftriaxone; genomic analysis; gonorrhea; in vitro susceptibility; phylogenic cluster; sexual transmitted infections; sexually transmitted disease.