Pharmacogenetic association with neurotoxicity in Hispanic children with acute lymphoblastic leukaemia

Br J Haematol. 2018 Jun;181(5):684-687. doi: 10.1111/bjh.14678. Epub 2017 Apr 17.
No abstract available

Keywords: acute leukaemia; acute lymphoblastic leukaemia; chemotherapy; childhood leukaemia; paediatric cancer.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Cytochrome P-450 CYP3A / genetics*
  • Female
  • Genotype*
  • Hispanic or Latino*
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Microtubule-Associated Proteins / genetics*
  • Neurotoxicity Syndromes / genetics*
  • Pharmacogenomic Testing
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma* / therapy
  • Vincristine* / administration & dosage
  • Vincristine* / adverse effects

Substances

  • CEP72 protein, human
  • Microtubule-Associated Proteins
  • Vincristine
  • CYP3A5 protein, human
  • Cytochrome P-450 CYP3A