Multiple Facial Trichoepitheliomas and Vulval Cysts: Extending the Phenotypic Spectrum in CYLD Cutaneous Syndrome

JAMA Dermatol. 2017 Aug 1;153(8):826-828. doi: 10.1001/jamadermatol.2017.0321.

Abstract

This case study describes a unique incidence of multiple trichoepitheliomas in combination with epidermoid cysts of the vulva in association with a novel pathogenic mutation in CYLD, extending the phenotypic spectrum.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / genetics*
  • DNA Mutational Analysis
  • Epidermal Cyst / diagnosis
  • Epidermal Cyst / genetics*
  • Female
  • Genetic Testing
  • Humans
  • Mutation*
  • Neoplastic Syndromes, Hereditary / diagnosis
  • Neoplastic Syndromes, Hereditary / genetics*
  • Phenotype
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / genetics*
  • Vulvar Diseases / diagnosis
  • Vulvar Diseases / genetics*
  • Young Adult

Substances

  • DNA

Supplementary concepts

  • Familial cylindromatosis