Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming

Ramon I Klein Geltink; David O'Sullivan; Erika L Pearce

doi:10.1016/j.immuni.2017.03.022

Caught in the cROSsfire: GSH Controls T Cell Metabolic Reprogramming

Immunity. 2017 Apr 18;46(4):525-527. doi: 10.1016/j.immuni.2017.03.022.

Authors

Ramon I Klein Geltink¹, David O'Sullivan¹, Erika L Pearce²

Affiliations

¹ Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.
² Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany. Electronic address: [email protected].

Abstract

T cell activation and proliferation critical for protective immunity depend on appropriate rewiring of cellular metabolism. In this issue of Immunity, Mak et al. (2017) show that the antioxidant gluthathione (GSH) controls reactive oxygen species (ROS)-dependent engagement of metabolic signaling pathways that lead to protective T cell responses.

Publication types

Comment

MeSH terms

Antioxidants
Glutathione*
Reactive Oxygen Species*
Signal Transduction
T-Lymphocytes

Substances

Antioxidants
Reactive Oxygen Species
Glutathione

Grants and funding

R01 CA181125/CA/NCI NIH HHS/United States