[Arterial infusion of anticancer agent and lipiodol using a totally implanted drug delivery system]

W Kishimoto; T Nonami; A Nakao; A Harada; K Kuroe; T Haba; H Takagi

[Arterial infusion of anticancer agent and lipiodol using a totally implanted drug delivery system]

Gan To Kagaku Ryoho. 1988 Aug;15(8 Pt 2):2531-4.

[Article in Japanese]

Authors

W Kishimoto¹, T Nonami, A Nakao, A Harada, K Kuroe, T Haba, H Takagi

Affiliation

¹ Second Dept. of Surgery, Nagoya University, School of Medicine.

PMID: 2843118

Abstract

We attempted arterial infusion of anticancer agent using a totally implanted drug delivery system in 52 patients who had inoperable liver cancer or the scheduled adjuvant chemotherapy after hepatic resection. The response rate of the cases using lipiodol was 38%, while that of the cases using only ADM and MMC was 0%. We studied changes in serum concentration of ADM and MMC. The results indicated that using 60% Urographin to make ADM, MMC-lipiodol emulsion was effective for targetting and control release.

Publication types

English Abstract

MeSH terms

Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Doxorubicin / administration & dosage
Drug Combinations
Emulsions
Fluorouracil / administration & dosage
Humans
Infusion Pumps*
Infusions, Intra-Arterial / methods
Iodized Oil / administration & dosage*
Liver Neoplasms / drug therapy*
Liver Neoplasms / secondary
Mitomycin
Mitomycins / administration & dosage
Remission Induction

Substances

Drug Combinations
Emulsions
Mitomycins
Mitomycin
Iodized Oil
Doxorubicin
Fluorouracil

Supplementary concepts

FAM protocol