Abstract
Platelet-derived growth factor (PDGF) mRNA, and mRNA for its receptor, have been localized to specific cell types within the human atherosclerotic plaque, using in situ hybridization. The predominant cell types found to express PDGF A and B chain mRNA are mesenchymal-appearing intimal cells and endothelial cells, respectively, with little or no expression detected in macrophages. The distribution of PDGF receptor mRNA containing cells was also examined and found to be localized predominantly in the plaque intima.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Arteriosclerosis / genetics
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Arteriosclerosis / metabolism
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Arteriosclerosis / pathology*
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Autoradiography
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Carotid Arteries
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Endothelium, Vascular / analysis
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Endothelium, Vascular / metabolism
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Endothelium, Vascular / pathology
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Humans
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Nucleic Acid Hybridization*
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Platelet-Derived Growth Factor / analysis
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Platelet-Derived Growth Factor / genetics
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Platelet-Derived Growth Factor / metabolism*
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RNA, Messenger / analysis
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RNA, Messenger / metabolism*
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Receptors, Cell Surface / analysis
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Receptors, Platelet-Derived Growth Factor
Substances
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Platelet-Derived Growth Factor
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RNA, Messenger
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Receptors, Cell Surface
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Receptors, Platelet-Derived Growth Factor