The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design

Christina Beatrice Karsten; Galit Alter

doi:10.1016/j.celrep.2017.04.033

The HIV-1 Glycan Shield: Strategically Placed Kinks in the Armor Improve Antigen Design

Cell Rep. 2017 Apr 25;19(4):669-670. doi: 10.1016/j.celrep.2017.04.033.

Authors

Christina Beatrice Karsten¹, Galit Alter²

Affiliations

¹ Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA.
² Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02139, USA. Electronic address: [email protected].

PMID: 28445718
DOI: 10.1016/j.celrep.2017.04.033

Abstract

Dense glycosylation on the HIV-1 envelope glycoprotein hampers the induction of broadly neutralizing antibodies against HIV-1. Zhou et al. remove key glycans to unmask sites of vulnerability and enable the induction of neutralizing antibodies.

Publication types

Comment

MeSH terms

Antibodies, Neutralizing
HIV Antibodies
HIV Envelope Protein gp120
HIV-1 / immunology*
Polysaccharides

Substances

Antibodies, Neutralizing
HIV Antibodies
HIV Envelope Protein gp120
Polysaccharides