The TMEM106B risk allele is associated with lower cortical volumes in a clinically diagnosed frontotemporal dementia cohort

J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):997-998. doi: 10.1136/jnnp-2017-315641. Epub 2017 Apr 26.

Authors

Sophie R Harding¹, Martina Bocchetta¹, Elizabeth Gordon¹, David M Cash^{1

2}, M Jorge Cardoso^{1

2}, Ron Druyeh³, Sebastian Ourselin^{1

2}, Jason D Warren¹, Simon Mead³, Jonathan D Rohrer¹

Affiliations

¹ Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
² Translational Imaging Group, Centre for Medical Image Computing (CMIC), University College London, London, UK.
³ MRC Prion Unit, Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.

No abstract available

Keywords: FRONTOTEMPORAL DEMENTIA; PRIMARY PROGRESSIVE APHASIA.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Alleles
Case-Control Studies
Cerebral Cortex / pathology*
Female
Frontotemporal Dementia / genetics*
Frontotemporal Dementia / pathology*
Humans
Male
Membrane Proteins / genetics*
Middle Aged
Nerve Tissue Proteins / genetics*
Organ Size
Polymorphism, Single Nucleotide / genetics*

Substances

Membrane Proteins
Nerve Tissue Proteins
TMEM106B protein, human

Grants and funding