Incidence of salivary side effects after radioiodine treatment using a new specifically-designed questionnaire

E Moreddu; K Baumstarck-Barrau; S Gabriel; N Fakhry; F Sebag; O Mundler; C Chossegros; D Taïeb

doi:10.1016/j.bjoms.2017.03.019

Incidence of salivary side effects after radioiodine treatment using a new specifically-designed questionnaire

Br J Oral Maxillofac Surg. 2017 Jul;55(6):609-612. doi: 10.1016/j.bjoms.2017.03.019. Epub 2017 Apr 26.

Authors

E Moreddu¹, K Baumstarck-Barrau², S Gabriel³, N Fakhry⁴, F Sebag⁵, O Mundler³, C Chossegros⁶, D Taïeb³

Affiliations

¹ Department of Maxillofacial Surgery, la Conception University Hospital, Aix-Marseille University, 147 Boulevard Baille, 13005 Marseille, France. Electronic address: [email protected].
² Unité d'Aide Méthodologique à la Recherche Clinique et Épidémiologique, Faculté de Médecine, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France.
³ Department of Nuclear Medicine, La Timone University Hospital, Aix-Marseille University, European Center of Research in Medical Imaging (CERIMED), 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France.
⁴ Department of Otorhinolaryngology and Cervico-Facial Surgery, la Conception University Hospital, Aix-Marseille University, 147 Boulevard Baille, 13005 Marseille, France.
⁵ Department of Endocrine Surgery, la Timone University Hospital, Aix-Marseille University, 264 rue Saint-Pierre, 13385 Marseille Cedex 5, France.
⁶ Department of Maxillofacial Surgery, la Conception University Hospital, Aix-Marseille University, 147 Boulevard Baille, 13005 Marseille, France.

PMID: 28456449
DOI: 10.1016/j.bjoms.2017.03.019

Abstract

Sialadenitis is one of the common complications of radioiodine treatment for thyroid malignancy. The aim of this study was to evaluate the prevalence of radioiodine-induced sialadenitis and other side effects by using a self-administered questionnaire. From 1 January 2011 to 31 December 2012 all consecutive patients with a newly-established diagnosis of thyroid cancer who were treated with adjuvant radioiodine at La Timone University Hospital were sent a self-administered questionnaire on salivary complaints that had been specifically designed for this study. A total of 413 patients sent the questionnaire back, of whom 100 (24%) had experienced pain, 116 (28%) discomfort or swelling, and 147 (36%) dry mouth or xerostomia. This survey has highlighted the number of side effects of radioiodine treatment in a large group of patients and corroborates previous observations. Our new self-administered questionnaire may be useful to others for follow-up and research.

Keywords: radioiodine; recombinant Human TSH; salivary; sialadenitis; thyroid neoplasm.

MeSH terms

Cohort Studies
Humans
Iodine Radioisotopes / adverse effects*
Sialadenitis / etiology*
Surveys and Questionnaires
Thyroid Neoplasms / radiotherapy*
Visual Analog Scale
Xerostomia / etiology*

Substances

Iodine Radioisotopes