Abstract
We describe here the synthesis of novel multivalent HIV V3 domain glycopeptides and their binding to broadly neutralizing antibodies PGT128 and 10-1074. Our binding data reveal a distinct mode of antigen recognition by the two antibodies and further suggest that multivalent glycopeptides could mimic the neutralizing epitopes more efficiently than the monomeric glycopeptide.
MeSH terms
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Antibody Specificity
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Glycopeptides*
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HIV Antibodies / physiology*
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HIV Envelope Protein gp120 / chemical synthesis*
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HIV-1 / physiology*
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Peptide Fragments / chemical synthesis*
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Polysaccharides / chemistry
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Polysaccharides / metabolism*
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Protein Binding
Substances
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Glycopeptides
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HIV Antibodies
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HIV Envelope Protein gp120
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HIV envelope protein gp120 (305-321)
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Peptide Fragments
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Polysaccharides