Metabolic Teamwork in the Stem Cell Niche

Cell Metab. 2017 May 2;25(5):993-994. doi: 10.1016/j.cmet.2017.04.019.

Abstract

Nearby cells can support stem cell differentiation, but the metabolic activities in stem cell niches are unknown. A recent study (Rodríguez-Colman et al., 2017) reveals a metabolic partnership in the intestinal stem cell niche: glycolysis in niche Paneth cells provides lactate to drive mitochondrial oxidative phosphorylation in intestinal stem cells.

MeSH terms

  • Animals
  • Cell Differentiation
  • Glycolysis
  • Humans
  • Intestinal Mucosa / metabolism
  • Intestines / cytology*
  • Lactic Acid / metabolism
  • Metabolic Networks and Pathways*
  • Metabolome
  • Mitochondria / metabolism
  • Oxidative Phosphorylation
  • Paneth Cells / cytology*
  • Paneth Cells / metabolism
  • Stem Cell Niche*
  • Stem Cells / cytology*
  • Stem Cells / metabolism

Substances

  • Lactic Acid