Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

Felix Sahm; Umut H Toprak; Daniel Hübschmann; Kortine Kleinheinz; Ivo Buchhalter; Martin Sill; Damian Stichel; Matthias Schick; Melanie Bewerunge-Hudler; Daniel Schrimpf; Gelareh Zadeh; Ken Aldape; Christel Herold-Mende; Katja Beck; Ori Staszewski; Marco Prinz; Carmit Ben Harosh; Roland Eils; Dominik Sturm; David T W Jones; Stefan M Pfister; Werner Paulus; Zvi Ram; Matthias Schlesner; Rachel Grossman; Andreas von Deimling

doi:10.1007/s00401-017-1715-9

Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature

Acta Neuropathol. 2017 Jul;134(1):155-158. doi: 10.1007/s00401-017-1715-9. Epub 2017 May 4.

Authors

Felix Sahm^{1

2}, Umut H Toprak³, Daniel Hübschmann^{3

4

5}, Kortine Kleinheinz³, Ivo Buchhalter³, Martin Sill⁶, Damian Stichel⁷, Matthias Schick⁸, Melanie Bewerunge-Hudler⁸, Daniel Schrimpf^{9

7}, Gelareh Zadeh^{10

11}, Ken Aldape^{10

12}, Christel Herold-Mende¹³, Katja Beck¹⁴, Ori Staszewski¹⁵, Marco Prinz^{15

16}, Carmit Ben Harosh¹⁷, Roland Eils^{3

4

14}, Dominik Sturm^{5

18}, David T W Jones¹⁸, Stefan M Pfister^{5

18}, Werner Paulus¹⁹, Zvi Ram^{17

20}, Matthias Schlesner³, Rachel Grossman^{17

20}, Andreas von Deimling^{21

22}

Affiliations

¹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. [email protected].
² Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [email protected].
³ Division of Theoretical Bioinformatics (B080), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁴ Department for Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology (IPMB) and BioQuant, Heidelberg University, Heidelberg, Germany.
⁵ Department of Pediatric Immunology, Hematology and Oncology, University Hospital Heidelberg, Heidelberg, Germany.
⁶ Division of Biostatistics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁷ Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁸ Genomics and Proteomics Core Facility, Microarray Unit, German Cancer Research Center (DKFZ), Heidelberg, Germany.
⁹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
¹⁰ McFeeters-Hamilton Centre for Neuro-oncology, Princess Margaret Cancer Centre, Toronto, Canada.
¹¹ Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Canada.
¹² Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
¹³ Division of Experimental Neurosurgery, Department of Neurosurgery, University Hospital Heidelberg, Heidelberg, Germany.
¹⁴ Heidelberg Center for Personalised Oncology (DKFZ-HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁵ Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
¹⁶ BIOSS Centre for Biological Signalling Studies, University of Freiburg, Freiburg, Germany.
¹⁷ Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.
¹⁸ Division of Pediatric Neurooncology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
¹⁹ Institute of Neuropathology, University Hospital Muenster, Muenster, Germany.
²⁰ Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
²¹ Department of Neuropathology, Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany. [email protected].
²² Clinical Cooperation Unit Neuropathology, German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [email protected].

PMID: 28474103
DOI: 10.1007/s00401-017-1715-9

No abstract available

Keywords: Meningioma; Mutational signatures; NF2; Radiation-induced tumors.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cohort Studies
Female
Humans
Male
Meningeal Neoplasms / etiology
Meningeal Neoplasms / genetics*
Meningioma / etiology
Meningioma / genetics*
Middle Aged
Mutation*
Neoplasms, Radiation-Induced / genetics*
Neurofibromin 2 / genetics*
Young Adult

Substances

Neurofibromin 2