Abstract
Clostridium septicum is a rare organism, accounting for approximately 1.3% of clostridial infections and is associated with synchronous colonic malignancy. This case report describes a patient successfully treated for a mycotic aortic aneurysm secondary to C. septicum bacteremia. Subsequent evaluation confirmed a colonic malignancy, prompting early intervention. A systematic literature review revealing a rate of gastrointestinal malignancy in this patient population is 71%, and hematologic malignancy is 3.9%, with the remaining cohort of patients having an unknown source. Infectious involvement of the aorta and associated vascular structures portends a poor prognosis with a 57% mortality rate. Our case and updated review demonstrates the implications of C. septicum vascular seeding and subsequent treatment outcomes.
Copyright © 2017 Elsevier Inc. All rights reserved.
Publication types
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Case Reports
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Review
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Systematic Review
MeSH terms
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Adenocarcinoma / diagnostic imaging
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Adenocarcinoma / microbiology*
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Adenocarcinoma / surgery
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Adult
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Aged
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Aged, 80 and over
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Aneurysm, Infected / diagnostic imaging
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Aneurysm, Infected / microbiology
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Aneurysm, Infected / surgery*
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Anti-Bacterial Agents / therapeutic use
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Aortic Aneurysm, Abdominal / diagnostic imaging
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Aortic Aneurysm, Abdominal / microbiology
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Aortic Aneurysm, Abdominal / surgery*
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Aortography / methods
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Biopsy
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Blood Vessel Prosthesis Implantation*
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Clostridium Infections / diagnostic imaging
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Clostridium Infections / microbiology
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Clostridium Infections / surgery*
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Clostridium septicum / isolation & purification*
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Colectomy
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Colonic Neoplasms / diagnostic imaging
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Colonic Neoplasms / microbiology*
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Colonic Neoplasms / surgery
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Colonoscopy
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Computed Tomography Angiography
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Early Detection of Cancer / methods
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Female
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Humans
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Male
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Middle Aged
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Treatment Outcome