Cytotoxic compounds against cancer cells from Bombyx mori inoculated with Cordyceps militaris

Biosci Biotechnol Biochem. 2017 Jun;81(6):1224-1226. doi: 10.1080/09168451.2017.1289075. Epub 2017 Feb 9.

Abstract

Two compounds, 3'-deoxyinosine and cordycepin, were isolated from Bombyx mori inoculated with Cordyceps militaris. In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells.

Keywords: Bombyx mori; Cordyceps militaris; cytotoxic compound; structural identification.

MeSH terms

  • A549 Cells
  • Animals
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology*
  • Bombyx / chemistry
  • Bombyx / microbiology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cordyceps / chemistry*
  • Cordyceps / growth & development
  • Cordyceps / metabolism
  • Deoxyadenosines / biosynthesis
  • Deoxyadenosines / isolation & purification
  • Deoxyadenosines / pharmacology*
  • Dose-Response Relationship, Drug
  • Host-Pathogen Interactions
  • Humans
  • Inosine / analogs & derivatives*
  • Inosine / biosynthesis
  • Inosine / isolation & purification
  • Inosine / pharmacology
  • Larva / chemistry
  • Larva / microbiology*
  • MCF-7 Cells

Substances

  • Antineoplastic Agents
  • Deoxyadenosines
  • 3'-deoxyinosine
  • Inosine
  • cordycepin