Abstract
Two compounds, 3'-deoxyinosine and cordycepin, were isolated from Bombyx mori inoculated with Cordyceps militaris. In the bioassay examining cytotoxicity against cancer cells, both compounds showed toxicity against A549, PANC-1, and MCF-7 cancer cells.
Keywords:
Bombyx mori; Cordyceps militaris; cytotoxic compound; structural identification.
MeSH terms
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A549 Cells
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Animals
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Bombyx / chemistry
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Bombyx / microbiology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Cordyceps / chemistry*
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Cordyceps / growth & development
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Cordyceps / metabolism
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Deoxyadenosines / biosynthesis
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Deoxyadenosines / isolation & purification
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Deoxyadenosines / pharmacology*
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Dose-Response Relationship, Drug
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Host-Pathogen Interactions
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Humans
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Inosine / analogs & derivatives*
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Inosine / biosynthesis
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Inosine / isolation & purification
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Inosine / pharmacology
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Larva / chemistry
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Larva / microbiology*
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MCF-7 Cells
Substances
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Antineoplastic Agents
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Deoxyadenosines
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3'-deoxyinosine
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Inosine
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cordycepin