A TIAM Double Hit to Oppose YAP/TAZ

Luca Azzolin; Stefano Piccolo

doi:10.1016/j.ccell.2017.04.009

A TIAM Double Hit to Oppose YAP/TAZ

Cancer Cell. 2017 May 8;31(5):607-608. doi: 10.1016/j.ccell.2017.04.009.

Authors

Luca Azzolin¹, Stefano Piccolo²

Affiliations

¹ Department of Molecular Medicine, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy.
² Department of Molecular Medicine, University of Padua School of Medicine, viale Colombo 3, 35126 Padua, Italy. Electronic address: [email protected].

Abstract

In this issue of Cancer Cell, Diamantopoulou et al. uncover dual mechanisms of inhibiting YAP/TAZ by TIAM1 that oppose invasiveness of colorectal cancer cells: TIAM1 interacts with TAZ in the cytoplasm to promote TAZ degradation by the destruction complex, whereas it antagonizes binding of TAZ/YAP to TEAD in the nucleus.

Publication types

Comment

MeSH terms

Adaptor Proteins, Signal Transducing*
Cell Nucleus
Colorectal Neoplasms
Humans
Phosphoproteins*
Signal Transduction
Transcription Factors

Substances

Adaptor Proteins, Signal Transducing
Phosphoproteins
Transcription Factors

Grants and funding

670126/ERC_/European Research Council/International