Activation of the release of dopamine in the carotid body by veratridine. Evidence for the presence of voltage-dependent Na+ channels in type I cells

A Rocher; A Obeso; B Herreros; C Gonzalez

doi:10.1016/0304-3940(88)90030-4

Activation of the release of dopamine in the carotid body by veratridine. Evidence for the presence of voltage-dependent Na+ channels in type I cells

Neurosci Lett. 1988 Dec 5;94(3):274-8. doi: 10.1016/0304-3940(88)90030-4.

Authors

A Rocher¹, A Obeso, B Herreros, C Gonzalez

Affiliation

¹ Departamento de Bioquimica, Facultad de Medicina, Universidad de Valladolid, Spain.

PMID: 2849733
DOI: 10.1016/0304-3940(88)90030-4

Abstract

Veratridine (50 microM), an agent known to activate voltage-dependent Na+ channels, induced a strong release of [3H]dopamine from the rabbit carotid body in vitro. The effect of veratridine was dependent on the presence of both Na+ and Ca2+ in the extracellular medium and was abolished by 1 microM tetrodotoxin. These results suggest that chemoreceptor type I cells have voltage-dependent Na+ channels, which could be involved in the depolarization of the cell membrane and activation of voltage-dependent Ca2+ channels.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Calcium / pharmacology
Carotid Body / cytology
Carotid Body / metabolism*
Dopamine / metabolism*
Dopamine Antagonists
In Vitro Techniques
Rabbits
Sodium / pharmacology
Sodium Channels / drug effects
Sodium Channels / metabolism*
Sodium Channels / physiology
Tetrodotoxin / pharmacology
Veratridine / pharmacology*
Veratrine / analogs & derivatives*

Substances

Dopamine Antagonists
Sodium Channels
Tetrodotoxin
Veratridine
Sodium
Veratrine
Calcium
Dopamine